Aadautech

Cancer Drug Discovery & Therapeutics Blog

Energy restriction can suppress pro-cancer effects

clock May 30, 2010 11:21 by author Dr. Nagaraj

Restriction of energy intake from food is the most effective single intervention for preventing cancer in experimental animals. It increases the lifespan of rodents, and suppresses tumor development in mice. In addition, energy restriction can suppress the pro-cancer effects of many carcinogens in experimental animal models.

Energy restriction leads to a reduction in cell proliferation. This may directly inhibit tumor growth, and also indirectly reducing cancer development by reducing overall proliferation, thus reducing the chances for incorrect DNA replication, or by preventing damaged DNA from being replicated. Reduced metabolism results in reduced generation of reactive oxygen species, and therefore less exposure of DNA to damaging oxygen radicals.

Dietary energy restriction reduces levels of circulating IGF-1 and insulin, which are growth factors for many cells, including breast cancer. Energy restriction also decreases expression of cyclins and cyclin-dependent kinases (CDKs), and increases levels of CDK inhibitors, leading to reduced Rb phosphorylation and inhibited cell cycle progression etc. The data on energy restriction have performed in experimental animals and relevance to humans is not yet clear.

Cancer cells also require oxygen to grow. But they spread at a very fast rate.  As a result, they outstrip the supply of blood to them. This results in shortage of oxygen in cancer cells. Cancer cells need a lot of energy to grow that fast and blood oxygen does not meet their demand, consequently they ferment glucose, but this route of energy production requires very large amounts of glucose. Lack of sugar energy makes the cancer cells eat their own selves. This process is called autophagy. Some cells commit apoptosis, which is the death of cells in a natural way. A natural product that works through energy restriction is Resveratrol, present in grapes and red wine. Energy restriction may offer a powerful new strategy for treating cancer because it targets a survival mechanism used by many types of cancer. (Report from Ohio State University Comprehensive Cancer Center, Journal of Biological Chemistry 2010).

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High temperature, and irritant drinks and foods may cause cancer

clock April 10, 2010 06:59 by author Dr. Nagaraj

Constant mechanical irritation of epithelial surfaces causes inflammation, which predisposes to the development of cancer. It has also been suggested that foods and drinks with chemically irritant components may be a cause of cancers of those sites with which they come into direct contact. Again there is not much evidence for this theory, with the possible exception of chilli and stomach of cancer.

There is, however, some evidence that some thermally hot drinks are a cause of cancers of those sites with which they come into direct contact. The mate (cimarron), an herbal infusion is probably a cause of cancer of the esophagus, and there is limited evidence suggesting that it is also a cause of other cancers of the oral cavity. It is because of the way the infusion is traditionally drunk in the pampas region within the southern cone of Latin America, in northern Argentina, Paraguay, and southern Brazil. It is drunk extremely hot from a gourd through a metal straw, which is often kept rested in the mouth, rather like the stem of tobacco pipe. There is also limited evidence suggesting that various other very hot drinks and foods are a cause of cancer of the esophagus when they are consumed regularly.

Some studies are looking into whether barbecued, fried and roasted meat cooked at high temperatures can increase the risk. These methods of cooking increase the content of chemicals called heterocyclic amines in food and these chemicals may increase cancer risk. (Ref).

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Epstein-Barr virus infection can cause nasopharyngeal cancer

clock March 23, 2010 11:28 by author Dr. Nagaraj

Epstein-Barr virus was the first human virus to be directly implicated in cancer development. Most adults are infected with the Epstein-Barr virus, but relatively few will ever develop the cancers of which this virus is a contributory or necessary cause. Other factors beyond infection with the virus are needed to lead to the development of cancer. Environmental factors including some dietary factors are thought to render precancerous epithelial cells sensitive to Epstein-Barr virus infection, which then triggers malignancy.

Epstein-Barr virus is a DNA virus of the herpes family. It is now known that Epstein-Barr virus infects >90% of the worlds adults population. Upon infection, the individual remains a lifelong carrier of the virus. It is transmitted by salivary contact. It primarily infects B lymphocytes (white blood cells that produce antibodies), though it can also infect epithelial cells. Infection usually occurs in childhood and does not usually produce symptoms, but in adults it can cause infectious mononucleosis or glandular fever. It is particularly associated with undifferentiated nasopharyngeal carcinoma, the most prevalent type.

In nasopharyngeal carcinoma, all of the tumor cells carry viral DNA in a monoclonal form. This means that Epstein-Barr virus infection must have occurred quite early in the cancer process, before rapid growth. It is not normally possible to detect Epstein-Barr virus infection in non-cancerous nasopharyngeal cells.

Therapy for Epstein-Barr virus associated cancer remains largely in the preliminary stages, but research is being fueled by the successful development of new antiviral and immunological approaches.

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Processed meat consumption increases the risk of cancer

clock March 11, 2010 02:00 by author Dr. Nagaraj

In the broad sense of the word, most meat is processed-cooking is a process. But as commonly used, the term ‘processed meat’ refers to meats (usually red meats) preserved by smoking, curing or salting, or by the addition of preservatives. Meats preserved only by refrigeration, however they are cooked, are usually not classified as ‘processed meat’.

Ham, bacon, pastrami, and salami are processed meats. So are sausages, bratwursts, frankfurters, and ‘hot dogs’ to which nitrites or nitrates or other preservatives are added. Minced meats sometimes fall inside this definition, often if they are preserved chemically, but not always. The same point applies to ‘ham burgers’. Given the importance of this issue, transnational burger caterers should specify the methods they use to process their products.

Nitrite or nitrate is used to preserve processed meats (it is extremely toxic to bacteria) and gives cured meats their recognizable colors and flavors. The addition of nitrite or nitrate to meat is regulated and monitored in most countries. Dietary nitrites and nitrates are probable human carcinogens because they are converted in the body to N-nitroso compounds which are known carcinogens and they have positive association with colon and pancreas cancer.

Parents should not feed ham or salami to their children often because processed meat increases the risk of developing cancer. The World Cancer Research Fund (WCRF) wants families to instead use poultry, fish, low-fat cheese, hummus or small amounts of lean meat as sandwich fillings when making up school lunchboxes. This may decrease their risk of developing cancer later in life.

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Foods containing dietary fiber can help to prevent cancer

clock February 9, 2010 17:14 by author Dr. Nagaraj

The concept of dietary fiber arose from observations of the low prevalence of colon cancer, diabetes and coronary heart disease in parts of Africa amongst people whose diets were high in unrefined carbohydrates and whose stools were typically bulky, and often or sometimes semisolid. Considerable efforts have been dedicated to characterizing the dietary component of what has come to be called dietary fiber is only derived from plant foods. Pulses (legumes) and minimally processed cereals are particularly concentrated sources, but vegetables and fruits also contain significant amounts. Dietary fiber isolated from plant cell walls and synthetic forms are increasingly entering the food supply.

High intakes of dietary fiber, variously defined, have been associated with reduced risk of some cancers. Definitions of dietary fiber vary. Some are based on chemical analyses of the components of plant cell walls, such as non-starch polysaccharides, others on physiological effects- the carbohydrates that enter the large bowel having escaped digestion in the small intestine being defined as dietary fiber. The World Health Organization (WHO) and Food and Agriculture Organization (FAO) have recently proposed that only polysaccharides which form part of plant cell walls should be regarded as dietary fiber.

A very large population trial namely “National Institutes of Health (NIH)- AARP diet and Health Study” investigated the role that dietary fiber may play in breast cancer rates. Over 185,000 postmenopausal women were followed for 7 years. Their findings suggest that dietary fiber can play a role in preventing breast cancer through non-estrogen pathways. (Ref: Park et al 2009).

Recently, Italian scientists provided very strong evidence that a high fiber diet can reduce the likelihood of stomach cancer occurrence.  (Ref: Bravi et al 2009).

Fiber Rich Foods (grams):  

  • Almonds (2 oz)=6 g
  • Avocado (100g)=7 g
  • Blackberries (100g)=5 g
  • Broccoli-cooked(1 cup)=6g
  • Chia seeds (1oz)=12g
  • 100% Cocoa powder (1oz)=9g
  • Coconut Fluor (1oz)=12g
  • Flax Seeds (1oz)=8g
  • Red Raspberries (100g)=6g
Reference: Reports from American Institute for Cancer Research

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Aadautech

The Cancer Drug Discovery & Therapeutics Blog was started in January 2009. It updates therapeutic targets and drug discovery in the area of cancer. Most of what you read here are updates of recent and new research in cancer therapeutics. Got a cancer news story you think belongs here? Lets discuss. So if you have an interest in cancer and cancer related discovery, please register and join others like you in an ongoing, vibrant dialog.

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