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Cancer Drug Discovery & Therapeutics Blog

Epstein-Barr virus infection can cause nasopharyngeal cancer

clock March 23, 2010 11:28 by author Dr. Nagaraj

Epstein-Barr virus was the first human virus to be directly implicated in cancer development. Most adults are infected with the Epstein-Barr virus, but relatively few will ever develop the cancers of which this virus is a contributory or necessary cause. Other factors beyond infection with the virus are needed to lead to the development of cancer. Environmental factors including some dietary factors are thought to render precancerous epithelial cells sensitive to Epstein-Barr virus infection, which then triggers malignancy.

Epstein-Barr virus is a DNA virus of the herpes family. It is now known that Epstein-Barr virus infects >90% of the worlds adults population. Upon infection, the individual remains a lifelong carrier of the virus. It is transmitted by salivary contact. It primarily infects B lymphocytes (white blood cells that produce antibodies), though it can also infect epithelial cells. Infection usually occurs in childhood and does not usually produce symptoms, but in adults it can cause infectious mononucleosis or glandular fever. It is particularly associated with undifferentiated nasopharyngeal carcinoma, the most prevalent type.

In nasopharyngeal carcinoma, all of the tumor cells carry viral DNA in a monoclonal form. This means that Epstein-Barr virus infection must have occurred quite early in the cancer process, before rapid growth. It is not normally possible to detect Epstein-Barr virus infection in non-cancerous nasopharyngeal cells.

Therapy for Epstein-Barr virus associated cancer remains largely in the preliminary stages, but research is being fueled by the successful development of new antiviral and immunological approaches.

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Processed meat consumption increases the risk of cancer

clock March 11, 2010 02:00 by author Dr. Nagaraj

In the broad sense of the word, most meat is processed-cooking is a process. But as commonly used, the term ‘processed meat’ refers to meats (usually red meats) preserved by smoking, curing or salting, or by the addition of preservatives. Meats preserved only by refrigeration, however they are cooked, are usually not classified as ‘processed meat’.

Ham, bacon, pastrami, and salami are processed meats. So are sausages, bratwursts, frankfurters, and ‘hot dogs’ to which nitrites or nitrates or other preservatives are added. Minced meats sometimes fall inside this definition, often if they are preserved chemically, but not always. The same point applies to ‘ham burgers’. Given the importance of this issue, transnational burger caterers should specify the methods they use to process their products.

Nitrite or nitrate is used to preserve processed meats (it is extremely toxic to bacteria) and gives cured meats their recognizable colors and flavors. The addition of nitrite or nitrate to meat is regulated and monitored in most countries. Dietary nitrites and nitrates are probable human carcinogens because they are converted in the body to N-nitroso compounds which are known carcinogens and they have positive association with colon and pancreas cancer.

Parents should not feed ham or salami to their children often because processed meat increases the risk of developing cancer. The World Cancer Research Fund (WCRF) wants families to instead use poultry, fish, low-fat cheese, hummus or small amounts of lean meat as sandwich fillings when making up school lunchboxes. This may decrease their risk of developing cancer later in life.

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Aadautech

The Cancer Drug Discovery & Therapeutics Blog was started in January 2009. It updates therapeutic targets and drug discovery in the area of cancer. Most of what you read here are updates of recent and new research in cancer therapeutics. Got a cancer news story you think belongs here? Lets discuss. So if you have an interest in cancer and cancer related discovery, please register and join others like you in an ongoing, vibrant dialog.

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