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Cancer Drug Discovery & Therapeutics Blog

Foods containing dietary fiber can help to prevent cancer

clock February 9, 2010 17:14 by author Dr. Nagaraj

The concept of dietary fiber arose from observations of the low prevalence of colon cancer, diabetes and coronary heart disease in parts of Africa amongst people whose diets were high in unrefined carbohydrates and whose stools were typically bulky, and often or sometimes semisolid. Considerable efforts have been dedicated to characterizing the dietary component of what has come to be called dietary fiber is only derived from plant foods. Pulses (legumes) and minimally processed cereals are particularly concentrated sources, but vegetables and fruits also contain significant amounts. Dietary fiber isolated from plant cell walls and synthetic forms are increasingly entering the food supply.

High intakes of dietary fiber, variously defined, have been associated with reduced risk of some cancers. Definitions of dietary fiber vary. Some are based on chemical analyses of the components of plant cell walls, such as non-starch polysaccharides, others on physiological effects- the carbohydrates that enter the large bowel having escaped digestion in the small intestine being defined as dietary fiber. The World Health Organization (WHO) and Food and Agriculture Organization (FAO) have recently proposed that only polysaccharides which form part of plant cell walls should be regarded as dietary fiber.

A very large population trial namely “National Institutes of Health (NIH)- AARP diet and Health Study” investigated the role that dietary fiber may play in breast cancer rates. Over 185,000 postmenopausal women were followed for 7 years. Their findings suggest that dietary fiber can play a role in preventing breast cancer through non-estrogen pathways. (Ref: Park et al 2009).

Recently, Italian scientists provided very strong evidence that a high fiber diet can reduce the likelihood of stomach cancer occurrence.  (Ref: Bravi et al 2009).

Fiber Rich Foods (grams):  

  • Almonds (2 oz)=6 g
  • Avocado (100g)=7 g
  • Blackberries (100g)=5 g
  • Broccoli-cooked(1 cup)=6g
  • Chia seeds (1oz)=12g
  • 100% Cocoa powder (1oz)=9g
  • Coconut Fluor (1oz)=12g
  • Flax Seeds (1oz)=8g
  • Red Raspberries (100g)=6g
Reference: Reports from American Institute for Cancer Research

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Phytochemicals, New Anti-Cancer Agents Discovered

clock February 6, 2010 04:10 by author Dr. Nagaraj

Plants contain a wide range of biologically active compounds, some of which are known as phytochemicals. There may be as many as 100000 different compounds, which determine particular properties in plants, and in the fruits and vegetables they produce, such as flavor and color. Phytochemicals are classified according to their chemical structure and functional characteristics, and include salicylates, phytosterols, saponins, glucosinolates, polyphenols, protease inhibitors, monoterpenes, phytoestrogens, sulphides, terpenes, and lectins.

It is widely believed that the health benefits of diets high in fruits and vegetables are likely to be due partly to the presence of phytochemicals. For instance, several act as antioxidants, preventing oxidative damage to cells, proteins, and DNA. It is likely that other bioactive phytochemicals have yet to be identified, and those that are known may have additional properties in the body that are not yet understood. But it is thought that nutrients, phytochemicals, and other, as yet unknown, bioactive components act together to influence physiological responses.

Although many phytochemicals are bioactive, they are not essential in the diet and there is no daily requirement, so they are not classed as nutrients. Humans have developed tastes for some phytochemicals, such as the hot flavors of mustard oil, bitter alkaloids, and irritating capsaicins. There is genetically inherited variation in sensitivity to some tastes, for example, the bitter taste of isothiocynates in cruciferous vegetables such as cabbage.

Examples of phytochemicals which can prevent cancer:

  • From veggie burgers to milk to protein bars, soy beans are known as a nutrient rich ingredient- there are studies showing soy bean can prevent prostate cancers.
  • Pomegranate phytochemical urolithin B suppresses estrogen production and that prevents the proliferation of breast cancer cells and the growth of estrogen-responsive tumors- Cancer Prevention Research, Jan 2010.
  • Phytochemicals (vitamins A, C, K, folate, carotenoids and lutein) from leafy veggies and green tea showed lower levels of genetic changes known to give rise to lung cancer in smokers-Cancer Research, Jan 2010.
  • Apples contain natural phytochemicals that have a protective effect against liver, breast and colon cancer-Journal of Agricultural and Food Chemistry, Apr 2008.
  • Mangos are known to be rich in vitamins C and A, as well as fiber. Polyphenolic compounds in mangos known as gallotannins, a class of natural bioactive compounds believed to help prevent or block the growth of cancer cells-Jan 2010.  http://agnews.tamu.edu/showstory.php?id=1686

Reference: Reports from American Institute for Cancer Research

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Aadautech

The Cancer Drug Discovery & Therapeutics Blog was started in January 2009. It updates therapeutic targets and drug discovery in the area of cancer. Most of what you read here are updates of recent and new research in cancer therapeutics. Got a cancer news story you think belongs here? Lets discuss. So if you have an interest in cancer and cancer related discovery, please register and join others like you in an ongoing, vibrant dialog.

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