Aadautech

Cancer Drug Discovery & Therapeutics Blog

Foods containing dietary fiber can help to prevent cancer

clock February 9, 2010 17:14 by author Dr. Nagaraj

The concept of dietary fiber arose from observations of the low prevalence of colon cancer, diabetes and coronary heart disease in parts of Africa amongst people whose diets were high in unrefined carbohydrates and whose stools were typically bulky, and often or sometimes semisolid. Considerable efforts have been dedicated to characterizing the dietary component of what has come to be called dietary fiber is only derived from plant foods. Pulses (legumes) and minimally processed cereals are particularly concentrated sources, but vegetables and fruits also contain significant amounts. Dietary fiber isolated from plant cell walls and synthetic forms are increasingly entering the food supply.

High intakes of dietary fiber, variously defined, have been associated with reduced risk of some cancers. Definitions of dietary fiber vary. Some are based on chemical analyses of the components of plant cell walls, such as non-starch polysaccharides, others on physiological effects- the carbohydrates that enter the large bowel having escaped digestion in the small intestine being defined as dietary fiber. The World Health Organization (WHO) and Food and Agriculture Organization (FAO) have recently proposed that only polysaccharides which form part of plant cell walls should be regarded as dietary fiber.

A very large population trial namely “National Institutes of Health (NIH)- AARP diet and Health Study” investigated the role that dietary fiber may play in breast cancer rates. Over 185,000 postmenopausal women were followed for 7 years. Their findings suggest that dietary fiber can play a role in preventing breast cancer through non-estrogen pathways. (Ref: Park et al 2009).

Recently, Italian scientists provided very strong evidence that a high fiber diet can reduce the likelihood of stomach cancer occurrence.  (Ref: Bravi et al 2009).

Fiber Rich Foods (grams):  

  • Almonds (2 oz)=6 g
  • Avocado (100g)=7 g
  • Blackberries (100g)=5 g
  • Broccoli-cooked(1 cup)=6g
  • Chia seeds (1oz)=12g
  • 100% Cocoa powder (1oz)=9g
  • Coconut Fluor (1oz)=12g
  • Flax Seeds (1oz)=8g
  • Red Raspberries (100g)=6g
Reference: Reports from American Institute for Cancer Research

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Phytochemicals, New Anti-Cancer Agents Discovered

clock February 6, 2010 04:10 by author Dr. Nagaraj

Plants contain a wide range of biologically active compounds, some of which are known as phytochemicals. There may be as many as 100000 different compounds, which determine particular properties in plants, and in the fruits and vegetables they produce, such as flavor and color. Phytochemicals are classified according to their chemical structure and functional characteristics, and include salicylates, phytosterols, saponins, glucosinolates, polyphenols, protease inhibitors, monoterpenes, phytoestrogens, sulphides, terpenes, and lectins.

It is widely believed that the health benefits of diets high in fruits and vegetables are likely to be due partly to the presence of phytochemicals. For instance, several act as antioxidants, preventing oxidative damage to cells, proteins, and DNA. It is likely that other bioactive phytochemicals have yet to be identified, and those that are known may have additional properties in the body that are not yet understood. But it is thought that nutrients, phytochemicals, and other, as yet unknown, bioactive components act together to influence physiological responses.

Although many phytochemicals are bioactive, they are not essential in the diet and there is no daily requirement, so they are not classed as nutrients. Humans have developed tastes for some phytochemicals, such as the hot flavors of mustard oil, bitter alkaloids, and irritating capsaicins. There is genetically inherited variation in sensitivity to some tastes, for example, the bitter taste of isothiocynates in cruciferous vegetables such as cabbage.

Examples of phytochemicals which can prevent cancer:

  • From veggie burgers to milk to protein bars, soy beans are known as a nutrient rich ingredient- there are studies showing soy bean can prevent prostate cancers.
  • Pomegranate phytochemical urolithin B suppresses estrogen production and that prevents the proliferation of breast cancer cells and the growth of estrogen-responsive tumors- Cancer Prevention Research, Jan 2010.
  • Phytochemicals (vitamins A, C, K, folate, carotenoids and lutein) from leafy veggies and green tea showed lower levels of genetic changes known to give rise to lung cancer in smokers-Cancer Research, Jan 2010.
  • Apples contain natural phytochemicals that have a protective effect against liver, breast and colon cancer-Journal of Agricultural and Food Chemistry, Apr 2008.
  • Mangos are known to be rich in vitamins C and A, as well as fiber. Polyphenolic compounds in mangos known as gallotannins, a class of natural bioactive compounds believed to help prevent or block the growth of cancer cells-Jan 2010.  http://agnews.tamu.edu/showstory.php?id=1686

Reference: Reports from American Institute for Cancer Research

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Can Refrigeration of Food Cause Cancer ?

clock January 31, 2010 03:41 by author Dr. Nagaraj

Freezing and cooling by use of natural ice and snow is a method of food preservation traditionally available only in cold climates or in winter in temperate climates. Natural ice refrigeration on an industrial scale first developed in the late 19th century, when refrigerated containers used in trains, ships, and then later trucks, greatly increased the production and consumption of red meat. Domestic freezing, chilling, and refrigeration on a mass scale is a phenomenon mostly of the second half of the 20th century.

Today, much perishable food is solid frozen or chilled. Together with the growth of industrial refrigeration, domestic refrigerators began to be used in the USA, Australia, and New Zealand on the scale in the 1920s, and the Europe and Japan mostly since the 1950s. In Japan, for example, household processing refrigerators increased from 9 per cent in 1960 to 91 per cent in 1970, and 99 per cent in 2004. Supermarkets with freezers, chill cabinets, and domestic refrigerators are now commonable in the cities and towns of tropical countries; poorer rural communities still rely on drying, fermenting, salting, bottling, tinning, and other methods of food preservation, as well as their own gardens and farms. It is unlikely that refrigeration itself has any direct effect on the risk of cancer. Their effects are indirect.

  • Refrigeration enables consumption of fresh perishable foods including seasonal vegetables and fruits all year round, as well as of fresh meat.
  • Refrigeration reduces microbial and fungal contamination of perishable foods, notably cereals (grains) and pulses (legumes).
  • Refrigeration reduces the need for and use of salting, smoking, curing, and pickling as methods of preserving vegetables, fruits and meat.

It can therefore be said that refrigeration (including freezing and chilling) indirectly influences risk of those cancers, the risk of which is affected by the above factors.

Evidence mounting to a judgement of ‘convincing’ or ‘probable’ for such factors relates to cancers of the mouth, pharynx, larynx, masopharynx, oesophagus, lung, stomach, pancreas, liver, and colon.

Reference: Reports from World Cancer Research Fund and American Institute for Cancer Research

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Aflatoxin Contamination Causes Cancer: A Worldwide Evaluation

clock January 9, 2010 03:00 by author Dr. Nagaraj

  Mycotoxins are toxins produced by certain moulds or fungi. Although moulds that contaminate foods are usually destroyed by cooking temperatures, the toxins they produce may remain. Aflatoxins are one type of mycotoxin. All naturally occurring aflatoxins are classified as human carcinogens (group 1) by International Agency for Research on Cancer; other mycotoxins, such as fumonisins, are suspected carcinogens. It is common to find co-contamination by more than one species of mycotoxin-producing fungus. In Europe, the joint FAO/WHO expert committee on Food Additives and Contaminants recommends that aflatoxin concentrations in foods be kept as low as possible.

The main foods that may be contaminated by aflatoxins are all types of cereal (grain), including wheat, rice, maize (corn), barley, and oats; and pulses (legumes)-notably peanuts. Nuts and seeds may also be contaminated. Feedstuffs for farm animals may also be contaminated with aflatoxins, which can then be secreted in milk or accumulated in tissues.

Aflatoxins, which are produced by Aspergillus flavus and A. parasiticus, are most problematic in countries with hot, damp climates and poor storage facilities. Under these conditions, food may become contaminated with fungi and then accumulate such toxins. Such foods are marketed and consumed in the countries in which they are produced; they are also exported to neighboring countries and intercontinentally. Aflatoxin contamination is therefore an international issue.

Levels of aflatoxin contamination tend to be highest in countries where rates of liver cancer are high, such as some African countries and South-East Asia, including China. In general, rates are low in Europe, but relatively high rates of contamination have on occasion been found in the USA. Aflatoxin exposure levels are low in Europe and Australia, higher in the USA, and high in many low-income countries. This is particularly the case in tropical and subtropical regions where grains and nuts are stored for long periods under non-ideal conditions.

Rates are reduced by inspection, use of fungicides, and screening of imported foods. However, monitoring of levels of aflatoxin contamination in low-income countries is generally lacking.

References: Reports from International Agency for research on Cancer, Food and Agriculture Organization of the United Nations, World Health Organization, United Nations Environment Program International, Third Joint FAO/WHO/UNEP International Conference on Mycotoxins, World Cancer Research fund and American Institute for Cancer Research.
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Natural Cures for Cancer Revealed in the Year 2009

clock January 2, 2010 06:43 by author Dr. Nagaraj

Study on grapeseed extract, vitamin D, spices (turmeric and black pepper), resveratrol, selenium and chaparral revealed that they are natural cures for many cancers.

Grapeseed extract kills leukemia cancer cells.

Prof. Xianglin Shi group from the University of Kentucky, USA have found a natural substance in the grape fruit that's deadly to malignant leukemia cells. Grapeseed is a natural compound that appears to have relatively important properties. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract. The scientists reported this study in the January 1, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

Vitamin D inhibits the growth of breast cancer tumors.

Activated form of vitamin D causes "cellular differentiation" - essentially the opposite of cancer. Vitamin D might have a protective role against breast cancer. Both sunlight and dietary exposure to vitamin D have correlated with a reduced risk of breast cancer. Results of one small study suggested that body stores of vitamin D may be associated with survival chances in women with advanced breast cancer. Study by Prof. Barbara Mawer, Manchester Royal Infirmary in central England.

Spices reduced the growth of breast stem cells.

Compounds derived from the spices turmeric and pepper could help prevent breast cancer by limiting the growth of stem cells. Dr. Madhuri Kakarala group at the University of Michigan Comprehensive Cancer Center, USA have found that when the dietary compounds curcumin, which is derived from the Indian spice turmeric, and piperine, derived from black peppers, were applied to breast cells in culture, they decreased the number of stem cells while having no effect on normal differentiated cells.

Resveratrol prevents cancer.

Resveratrol is a naturally occurring phytoalexin produced by some higher plants in response to injury or fungal infection. Resveratrol is abundant in the skins of red grapes. Grape juice contains resveratrol, as does cranberry juice, but at levels that are ten times less than those in red. Resveratrol concentration in red wine varies greatly from one grape variety to another and from one region to another. When incubated with hepatoma cells, resveratrol induced Phase II detoxifying enzymes that detoxified and inhibited the proliferation of these cells. Grape skins, leaves, juice and red wine are all good sources of resveratrol. Resource by Richard Beliveau et al., in the book ‘Foods That Fight Cancer’.

Selenium helps prevent cancer.

Selenium is found in soil, and human consumption comes by eating plants that have absorbed the nutrient or fish or animals that have eaten plants as part of their diet. “The content of selenium in the food depends on the soil content of this trace element. Supplemental selenium could reduce cancer death rates by as much as 50%. 1,312 patients were given 200 mcg. of selenium daily. The patients receiving selenium had a rise of 67% in their blood selenium level. The patients receiving selenium had a 67% decrease in cancer of the prostate, a 58 percent decrease in colon or rectal cancer and a 45% decrease in lung cancer. This suggests that possibly up to 100,000 lives a year might be saved in the USA by the simple addition of selenium to the diet. -A Physicians Guide to Natural Health Products That Work  by James A. Howenstine, MD.

Chaparral treats cancer.

The plant is the creosote bush, or chaparral, also known as greasewood, and is a member of the oak family, has been used by Native Americans to treat a variety of illnesses, including cancer. Chaparral contains an ingredient called nor-dihihydroguairetic (NDGA), a potent antitumor agent. NDGA inhibits aerobic and anaerobic glycolysis (the energy-producing ability) of cancer cells. - Herbal Medicine, Healing and Cancer by Donald Yance and Arlene Valentine.

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Aadautech

The Cancer Drug Discovery & Therapeutics Blog was started in January 2009. It updates therapeutic targets and drug discovery in the area of cancer. Most of what you read here are updates of recent and new research in cancer therapeutics. Got a cancer news story you think belongs here? Lets discuss. So if you have an interest in cancer and cancer related discovery, please register and join others like you in an ongoing, vibrant dialog.

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